{"id":434413,"date":"2026-08-24T17:24:37","date_gmt":"2026-08-24T09:24:37","guid":{"rendered":"https:\/\/library.usj.edu.mo\/?post_type=tnc_col_19837_item&#038;p=434413"},"modified":"2026-08-24T18:31:54","modified_gmt":"2026-08-24T10:31:54","slug":"ccaat-enhancer-binding-protein-alpha-is-a-novel-regulator-of-vascular-smooth-muscle-cell-osteochondrogenic-transition-and-vascular-calcification","status":"publish","type":"tnc_col_19837_item","link":"https:\/\/library.usj.edu.mo\/zh\/scholarly-work-usj\/ccaat-enhancer-binding-protein-alpha-is-a-novel-regulator-of-vascular-smooth-muscle-cell-osteochondrogenic-transition-and-vascular-calcification\/","title":{"rendered":"CCAAT\/ENHANCER-BINDING PROTEIN ALPHA IS A NOVEL REGULATOR OF VASCULAR SMOOTH MUSCLE CELL OSTEOCHONDROGENIC TRANSITION AND VASCULAR CALCIFICATION"},"content":{"rendered":"<p>AIMSVASCULAR CALCIFICATION IS A COMMON CLINICAL COMPLICATION OF CHRONIC KIDNEY DISEASE (CKD), ATHEROSCLEROSIS (AS), AND DIABETES, WHICH IS ASSOCIATED WITH INCREASED CARDIOVASCULAR MORBIDITY AND MORTALITY IN PATIENTS. THE TRANSDIFFERENTIATION OF VASCULAR SMOOTH MUSCLE CELLS (VSMCS) TO AN OSTEOCHONDROGENIC PHENOTYPE IS A CRUCIAL STEP DURING VASCULAR CALCIFICATION. THE TRANSCRIPTION FACTOR CCAAT\/ENHANCER-BINDING PROTEIN ALPHA (C\/EBP\u0391) PLAYS AN IMPORTANT ROLE IN REGULATING CELL PROLIFERATION AND DIFFERENTIATION, BUT WHETHER IT REGULATES THE CALCIFICATION OF ARTERIES AND VSMCS REMAINS UNCLEAR. THEREFORE, THIS STUDY AIMS TO UNDERSTAND THE ROLE OF C\/EBP\u0391 IN THE REGULATION OF VASCULAR CALCIFICATION.METHODS AND RESULTSBOTH MRNA AND PROTEIN EXPRESSION LEVELS OF C\/EBP\u0391 WERE SIGNIFICANTLY INCREASED IN CALCIFIED ARTERIES FROM MICE TREATED WITH A HIGH DOSE OF VITAMIN D3 (VD3). UPREGULATION OF C\/EBP\u0391 WAS ALSO OBSERVED IN THE HIGH PHOSPHATE- AND CALCIUM-INDUCED VSMC CALCIFICATION PROCESS. THE SIRNA-MEDIATED KNOCKDOWN OF C\/EBP\u0391 SIGNIFICANTLY ATTENUATED VSMC CALCIFICATION IN VITRO. MOREOVER, C\/EBP\u0391 DEPLETION IN VSMCS SIGNIFICANTLY REDUCED THE MRNA EXPRESSION OF THE OSTEOCHONDROGENIC GENES, E.G., SEX-DETERMINING REGION Y-BOX 9 (SOX9). C\/EBP\u0391 OVEREXPRESSION CAN INDUCE SOX9 OVEREXPRESSION. SIMILAR CHANGES IN THE PROTEIN EXPRESSION OF SOX9 WERE ALSO OBSERVED IN VSMCS AFTER C\/EBP\u0391 DEPLETION OR OVEREXPRESSION. IN ADDITION, SILENCING OF SOX9 EXPRESSION SIGNIFICANTLY INHIBITED THE PHOSPHATE- AND CALCIUM-INDUCED VSMC CALCIFICATION IN VITRO.CONCLUSIONFINDINGS IN THIS STUDY INDICATE THAT C\/EBP\u0391 IS A KEY REGULATOR OF THE OSTEOCHONDROGENIC TRANSDIFFERENTIATION OF VSMCS AND VASCULAR CALCIFICATION, WHICH MAY REPRESENT A NOVEL THERAPEUTIC TARGET FOR VASCULAR CALCIFICATION.<\/p>","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","format":"standard","class_list":["post-434413","tnc_col_19837_item","type-tnc_col_19837_item","status-publish","format-standard","hentry","tnc_tax_19818-english","tnc_tax_19716-institute-of-science-and-environment","tnc_tax_19659-journal-article"],"taxonomy_info":[],"featured_image_src_large":false,"author_info":[],"comment_info":0,"featured_img":false,"coauthors":[],"author_meta":{"author_link":"https:\/\/library.usj.edu.mo\/zh\/author\/emilychan\/","display_name":"emily chan"},"relative_dates":{"created":"Posted 4 \u5929 ago","modified":"Updated 4 \u5929 ago"},"absolute_dates":{"created":"Posted on 24 8 \u6708, 2026","modified":"Updated on 24 8 \u6708, 2026"},"absolute_dates_time":{"created":"Posted on 24 8 \u6708, 2026 5:24 \u4e0b\u5348","modified":"Updated on 24 8 \u6708, 2026 6:31 \u4e0b\u5348"},"featured_img_caption":"","tax_additional":{"tnc_tax_19993":{"linked":[],"unlinked":[],"slug":"tnc_tax_19993","name":"SDGs"},"tnc_tax_19818":{"linked":["<a href=\"https:\/\/library.usj.edu.mo\/zh\/language\/english\/\" class=\"advgb-post-tax-term\">ENGLISH<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">ENGLISH<\/span>"],"slug":"tnc_tax_19818","name":"LANGUAGE"},"tnc_tax_19716":{"linked":["<a href=\"https:\/\/library.usj.edu.mo\/zh\/faculty-research-unit\/institute-of-science-and-environment\/\" class=\"advgb-post-tax-term\">INSTITUTE OF SCIENCE AND ENVIRONMENT<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">INSTITUTE OF SCIENCE AND ENVIRONMENT<\/span>"],"slug":"tnc_tax_19716","name":"FACULTY \/ RESEARCH UNIT"},"tnc_tax_19664":{"linked":[],"unlinked":[],"slug":"tnc_tax_19664","name":"SUBJECT"},"tnc_tax_19659":{"linked":["<a href=\"https:\/\/library.usj.edu.mo\/zh\/resource-type\/journal-article\/\" class=\"advgb-post-tax-term\">Journal Article<\/a>"],"unlinked":["<span class=\"advgb-post-tax-term\">Journal Article<\/span>"],"slug":"tnc_tax_19659","name":"Document Type"}},"series_order":"","_links":{"self":[{"href":"https:\/\/library.usj.edu.mo\/zh\/wp-json\/wp\/v2\/tnc_col_19837_item\/434413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/library.usj.edu.mo\/zh\/wp-json\/wp\/v2\/tnc_col_19837_item"}],"about":[{"href":"https:\/\/library.usj.edu.mo\/zh\/wp-json\/wp\/v2\/types\/tnc_col_19837_item"}],"replies":[{"embeddable":true,"href":"https:\/\/library.usj.edu.mo\/zh\/wp-json\/wp\/v2\/comments?post=434413"}],"version-history":[{"count":1,"href":"https:\/\/library.usj.edu.mo\/zh\/wp-json\/wp\/v2\/tnc_col_19837_item\/434413\/revisions"}],"predecessor-version":[{"id":435635,"href":"https:\/\/library.usj.edu.mo\/zh\/wp-json\/wp\/v2\/tnc_col_19837_item\/434413\/revisions\/435635"}],"wp:attachment":[{"href":"https:\/\/library.usj.edu.mo\/zh\/wp-json\/wp\/v2\/media?parent=434413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}