ASSESSMENT OF THE POST-ACUTE COVID-19 SYNDROME CARDIOVASCULAR EFFECT THROUGH ECG ANALYSIS

摘要

INTRODUCTION: SARS-COV-2, A VIRUS RESPONSIBLE FOR THE EMERGENCE OF THE LIFE-THREATENING DISEASE KNOWN AS COVID-19, EXHIBITS A DIVERSE RANGE OF CLINICAL MANIFESTATIONS. THE SPECTRUM OF SYMPTOMS VARIES WIDELY, ENCOMPASSING MILD TO SEVERE PRESENTATIONS, WHILE A CONSIDERABLE PORTION OF THE POPULATION REMAINS ASYMPTOMATIC. COVID-19, PRIMARILY A RESPIRATORY VIRUS, HAS BEEN LINKED TO CARDIOVASCULAR COMPLICATIONS IN SOME PATIENTS. NOTABLY, CARDIAC ISSUES CAN ALSO ARISE AFTER RECOVERY, CONTRIBUTING TO POST-ACUTE COVID-19 SYNDROME, A SIGNIFICANT CONCERN FOR PATIENT HEALTH. THE PRESENT STUDY INTENDS TO EVALUATE THE POST-ACUTE COVID-19 SYNDROME CARDIOVASCULAR EFFECT THROUGH ECG BY COMPARING PATIENTS AFFECTED WITH CARDIAC DISEASES WITHOUT COVID-19 DIAGNOSIS REPORT (CLASS 1) AND PATIENTS WITH CARDIAC PATHOLOGIES WHO PRESENT POST-ACUTE COVID-19 SYNDROME (CLASS 2). METHODS: FROM 2 BODY POSITIONS, A TOTAL OF 10 NON-LINEAR FEATURES, EXTRACTED EVERY 1 SECOND UNDER A MULTI-BAND ANALYSIS PERFORMED BY DISCRETE WAVELET TRANSFORM (DWT), HAVE BEEN COMPRESSED BY 6 STATISTICAL METRICS TO SERVE AS INPUTS FOR AN INDIVIDUAL FEATURE ANALYSIS BY THE MEANS OF MANN-WHITNEY U-TEST AND XROC CLASSIFICATION. RESULTS AND DISCUSSION: 480 MANN-WHITNEY U-TEST STATISTICAL ANALYSES AND XROC DISCRIMINATION APPROACHES HAVE BEEN DONE. THE PERCENTAGE OF STATISTICAL ANALYSIS WITH SIGNIFICANT DIFFERENCES (P<0.05) WAS 30.42% (146 OUT OF 480). THE BEST OVERALL RESULTS WERE OBTAINED BY APPROXIMATING THE FEATURE ENERGY, WITH THE DATA COMPRESSOR KURTOSIS IN THE BODY POSITION DOWN. THOSE RESULTS WERE 83.33% OF ACCURACY, 83.33% OF SENSITIVITY, 83.33% OF SPECIFICITY AND 87.50% OF AUC. CONCLUSIONS: THE RESULTS SHOW THAT THE APPLIED METHODOLOGY CAN BE A WAY TO SHOW CHANGES IN CARDIAC BEHAVIOUR PROVOKED BY POST-ACUTE COVID-19 SYNDROME.